A team of scientists afresh conducted a first-of-its-kind agreement to study the furnishings of space radiation on a living brain. And the after-effects don’t bode well for NASA‘s planned mission to Mars.

The analysis was conducted by lead author Charles Limoli and scientists from University of California, Irvine, Stanford University, Colorado State University, and the Eastern Virginia School of Medicine. It complex using a new neutron betterment ability to expose class mice to the same levels of radiation they’d acquaintance in space.

According to the team’s paper:

We have baldheaded that realistic, low dose rate exposures aftermath austere neurocognitive complications associated with broken neurotransmission. Chronic (6 month) low dose (18 cGy) and dose rate (192 mGy/day) exposures … result in beneath hippocampal neuronal affect and disrupted hippocampal and cortical abiding potentiation.

Furthermore, mice displayed severe impairments in acquirements and memory, and the actualization of ache behaviors. Behavioral analyses showed an alarming access in risk associated with these astute simulations, absolute for the first time, some abrupt abeyant problems associated with deep space travel on all levels of acoustic function.

Cognitive abatement accompanying to space travel is a big deal for humans because all break are that it’s permanent. After US astronaut Scott Kelly spent 340 days in space aboard the Mir space station, all-encompassing testing showed his cerebral abilities had decreased.

Limoli’s team bent that it’s likely one in five astronauts traveling through deep space for an continued period of time would acquaintance anxiety-like symptoms, while one in three would suffer memory loss. This data, according to the team, “suggests that the accident of severe impairments in acquirements and memory, and the actualization of ache behaviors may occur in an unacceptably high allotment of astronauts.”

Read next: Report: Rockstar offers contractors full-time work after crunch altercation